/* Extracted from Flask template <style> blocks for Cloudflare parity. */


/* lbd.html style block 1 */
/* Hide Molstar viewport controls */
.structure-viewer .msp-viewport-controls,
.structure-viewer .msp-viewport-controls-buttons,
.structure-viewer .msp-viewport-controls-panel,
.structure-viewer .msp-viewport-controls-panel-controls,
.structure-viewer .msp-viewport-top-left-controls,
.structure-viewer .msp-layout-left,
.structure-viewer .msp-left-panel-controls {
    display: none !important;
    visibility: hidden !important;
}

/* LBD Page Styles */
.lbd-page {
    width: 100%;
}

/* Tab Navigation */
.lbd-tabs {
    display: flex;
    gap: 4px;
    background: var(--color-gray-100);
    padding: 6px;
    border-radius: var(--radius-lg);
    margin-bottom: 24px;
    width: fit-content;
}

.lbd-tab {
    display: flex;
    align-items: center;
    gap: 8px;
    padding: 12px 24px;
    border: none;
    background: transparent;
    color: var(--color-gray-600);
    font-size: 0.95rem;
    font-weight: 500;
    border-radius: var(--radius-md);
    cursor: pointer;
    transition: all 0.2s ease;
}

.lbd-tab:hover {
    background: var(--color-gray-200);
    color: var(--color-gray-800);
}

.lbd-tab.active {
    background: white;
    color: var(--color-primary);
    box-shadow: var(--shadow-sm);
}

.lbd-tab svg {
    flex-shrink: 0;
}

/* Tab Content */
.lbd-tab-content {
    display: none;
}

.lbd-tab-content.active {
    display: block;
}

/* Sortable Table Headers */
.sortable {
    cursor: pointer;
    user-select: none;
    transition: background-color 0.2s ease;
}

.sortable:hover {
    background-color: rgba(59, 130, 246, 0.1);
}

.sortable.active {
    background-color: rgba(59, 130, 246, 0.15);
}

.sort-header {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    white-space: nowrap;
}

.sort-icon {
    font-size: 0.75rem;
    opacity: 0.5;
    transition: opacity 0.2s ease, transform 0.2s ease;
}

.sortable:hover .sort-icon {
    opacity: 0.8;
}

.sortable.active .sort-icon {
    opacity: 1;
    color: var(--color-primary);
}

.sortable.desc .sort-icon {
    color: #dc2626;
}

.sortable.asc .sort-icon {
    color: #16a34a;
}

/* Structure Gallery Styles */
.structure-gallery-section {
    background: white;
    padding: 16px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-bottom: 24px;
}

.gallery-header {
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    justify-content: space-between;
    gap: 8px;
    margin-bottom: 12px;
}

.gallery-header h2 {
    margin: 0;
    font-size: 1.1rem;
    color: var(--color-gray-900);
}

.gallery-subtitle {
    color: var(--color-gray-500);
    font-size: 0.875rem;
    margin: 0;
    flex-basis: 100%;
}

.gallery-controls {
    display: flex;
    align-items: center;
    gap: 12px;
}

.structure-gallery {
    display: grid;
    grid-template-columns: repeat(6, 1fr);
    gap: 12px;
}

.gallery-loading {
    grid-column: 1 / -1;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 10px;
    padding: 40px;
    color: var(--color-gray-500);
}

.spinner {
    width: 24px;
    height: 24px;
    border: 3px solid var(--color-gray-200);
    border-top-color: var(--color-primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
}

@keyframes spin {
    to { transform: rotate(360deg); }
}

.structure-card {
    background: var(--color-gray-50);
    border-radius: var(--radius-lg);
    overflow: hidden;
    transition: all 0.3s ease;
    border: 1px solid var(--color-gray-200);
}

.structure-card:hover {
    box-shadow: var(--shadow-md);
    border-color: var(--color-primary);
}

.structure-viewer {
    width: 100%;
    height: 160px;
    background: linear-gradient(135deg, #1a1a2e 0%, #16213e 100%);
    position: relative;
}

.structure-viewer .no-structure {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    color: var(--color-gray-400);
    font-size: 0.75rem;
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

.structure-info {
    display: block;
    padding: 8px 10px;
    text-decoration: none;
    color: inherit;
    cursor: pointer;
}

.structure-info:hover {
    background: var(--color-gray-100);
}

.structure-title {
    display: block;
    font-weight: 600;
    color: var(--color-gray-900);
    text-decoration: none;
    font-size: 0.7rem;
    margin-bottom: 2px;
    word-break: break-all;
    line-height: 1.2;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
}

.structure-card:hover .structure-title {
    color: var(--color-primary);
}

.structure-meta {
    margin-bottom: 4px;
}

.target-link {
    font-size: 0.65rem;
    color: var(--color-gray-500);
    text-transform: uppercase;
    letter-spacing: 0.02em;
}

.structure-rates {
    display: flex;
    gap: 3px;
    flex-wrap: wrap;
}

.rate-badge, .metric-badge {
    font-size: 0.6rem;
    padding: 1px 4px;
    border-radius: 3px;
    font-weight: 500;
}

.rate-badge.colabdesign {
    background: rgba(16, 185, 129, 0.15);
    color: #059669;
}

.rate-badge.rfd {
    background: rgba(245, 158, 11, 0.15);
    color: #d97706;
}

.rate-badge.mpnn {
    background: rgba(59, 130, 246, 0.15);
    color: #2563eb;
}

.rate-badge.triflow {
    background: rgba(168, 85, 247, 0.15);
    color: #9333ea;
}

.metric-badge {
    background: var(--color-gray-100);
    color: var(--color-gray-600);
}

.gallery-error {
    grid-column: 1 / -1;
    text-align: center;
    padding: 40px;
    color: var(--color-gray-500);
}

.pdb-external-link {
    display: inline-block;
    margin-left: 8px;
    padding: 2px 8px;
    font-size: 0.7rem;
    font-weight: 500;
    color: var(--color-primary);
    background: rgba(59, 130, 246, 0.1);
    border-radius: 4px;
    text-decoration: none;
    transition: all 0.2s ease;
}

.pdb-external-link:hover {
    background: rgba(59, 130, 246, 0.2);
    color: var(--color-primary-dark, #1d4ed8);
}

/* Introduction section */
.intro-section {
    margin-bottom: 12px;
    padding: 10px 16px;
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
}

.intro-content p {
    margin: 0;
    color: var(--color-gray-700);
    line-height: 1.5;
    font-size: 0.875rem;
}

.intro-content strong {
    color: var(--color-gray-900);
}

/* Table legend */
.table-legend {
    margin-bottom: 10px;
    padding: 10px 16px;
    background: white;
    border: 1px solid var(--color-gray-200);
    border-radius: var(--radius-md);
}

.table-legend h3 {
    margin: 0 0 8px 0;
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--color-gray-700);
}

.legend-items {
    display: flex;
    flex-wrap: wrap;
    gap: 12px 24px;
}

.legend-item {
    display: flex;
    align-items: center;
    gap: 8px;
}

.legend-label {
    font-weight: 500;
    color: var(--color-gray-600);
    font-size: 0.85rem;
}

.legend-desc {
    color: var(--color-gray-500);
    font-size: 0.85rem;
}

.legend-item .pipeline-badge,
.legend-item .tool-label {
    padding: 2px 8px;
    border-radius: 4px;
    font-size: 0.75rem;
    font-weight: 600;
}

.legend-item .pipeline-badge.colabdesign {
    background: rgba(34, 197, 94, 0.1);
    color: #16a34a;
}

.legend-item .pipeline-badge.rfd {
    background: rgba(249, 115, 22, 0.1);
    color: #ea580c;
}

.legend-item .tool-label.triflow {
    background: rgba(139, 92, 246, 0.1);
    color: #7c3aed;
}

.legend-item .tool-label.mpnn {
    background: rgba(59, 130, 246, 0.1);
    color: #2563eb;
}

/* Table row index and count styles */
.row-index-header,
.row-index {
    width: 40px;
    text-align: center;
    color: var(--color-gray-500);
    font-size: 0.85rem;
}

.count-cell {
    text-align: center;
}

.structure-count-value {
    font-weight: 600;
    color: var(--color-gray-700);
}

/* Responsive adjustments */
@media (max-width: 1200px) {
    .structure-gallery {
        grid-template-columns: repeat(4, 1fr);
    }
}

@media (max-width: 900px) {
    .structure-gallery {
        grid-template-columns: repeat(3, 1fr);
    }
}

@media (max-width: 768px) {
    .structure-gallery {
        grid-template-columns: repeat(2, 1fr);
    }

    .gallery-header {
        flex-direction: column;
        align-items: flex-start;
    }

    .gallery-controls {
        width: 100%;
        justify-content: space-between;
    }

    .lbd-tabs {
        width: 100%;
    }

    .lbd-tab {
        flex: 1;
        justify-content: center;
    }
}

@media (max-width: 480px) {
    .structure-gallery {
        grid-template-columns: 1fr;
    }
}


/* target_detail.html style block 1 */
.pdb-external-link {
    display: inline-block;
    margin-left: 12px;
    padding: 4px 12px;
    font-size: 0.8rem;
    font-weight: 500;
    color: var(--color-primary);
    background: rgba(59, 130, 246, 0.1);
    border-radius: 6px;
    text-decoration: none;
    transition: all 0.2s ease;
}

.pdb-external-link:hover {
    background: rgba(59, 130, 246, 0.2);
    color: var(--color-primary-dark, #1d4ed8);
}

.success-rates-section, .native-structure-section, .designs-section, .actions-section {
    background: white;
    padding: 16px;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
    margin-bottom: 12px;
}

.rates-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 16px;
}

.rate-card {
    padding: 14px;
    border-radius: var(--radius-md);
    background: var(--color-gray-50);
}

.rate-card.colabdesign {
}

.rate-card.rfd {
}

.rate-card h3 {
    margin-bottom: 10px;
    font-size: 0.95rem;
}

.rate-row {
    display: flex;
    align-items: center;
    gap: 12px;
    margin-bottom: 12px;
}

.rate-row .tool-label {
    width: 70px;
    flex-shrink: 0;
    padding: 4px 8px;
    border-radius: 4px;
    font-size: 0.875rem;
    font-weight: 600;
    text-align: center;
}

.rate-row .tool-label.mpnn {
    background: rgba(59, 130, 246, 0.1);
    color: var(--color-mpnn);
}

.rate-row .tool-label.triflow {
    background: rgba(139, 92, 246, 0.1);
    color: var(--color-triflow);
}

.rate-bar-large {
    flex: 1;
    height: 24px;
    background: var(--color-gray-200);
    border-radius: 12px;
    overflow: hidden;
}

.structure-count {
    font-size: 1.1rem;
    font-weight: 500;
    color: var(--color-gray-700);
    text-align: left;
}

.rate-comparison {
    text-align: center;
    padding-top: 12px;
    border-top: 1px solid var(--color-gray-200);
    margin-top: 8px;
}

.winner {
    padding: 4px 12px;
    border-radius: 12px;
    font-size: 0.875rem;
    font-weight: 600;
}

.winner.mpnn {
    background: rgba(59, 130, 246, 0.1);
    color: var(--color-mpnn);
}

.winner.triflow {
    background: rgba(139, 92, 246, 0.1);
    color: var(--color-triflow);
}

.tie {
    color: var(--color-gray-500);
}

.winner-text {
    color: var(--color-gray-700);
    font-weight: 500;
}

.config-designs {
    margin-bottom: 32px;
}

.config-designs h3 {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 16px;
}

.design-count {
    color: var(--color-gray-500);
    font-weight: normal;
    font-size: 0.875rem;
}

.designs-table-wrapper {
    overflow-x: auto;
}

.more-designs {
    padding: 16px;
    text-align: center;
}

.section-subtitle {
    color: var(--color-gray-500);
    margin-bottom: 24px;
}

.actions-grid {
    display: flex;
    gap: 12px;
    flex-wrap: wrap;
}

/* Designs Header with View Toggle */
.designs-header {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    margin-bottom: 24px;
    flex-wrap: wrap;
    gap: 16px;
}

.designs-header h2 {
    margin-bottom: 4px;
}

.view-toggle {
    display: flex;
    gap: 4px;
    background: var(--color-gray-100);
    padding: 4px;
    border-radius: var(--radius-md);
}

.view-btn {
    display: flex;
    align-items: center;
    gap: 6px;
    padding: 8px 16px;
    border: none;
    background: transparent;
    border-radius: var(--radius-sm);
    cursor: pointer;
    font-size: 0.875rem;
    font-weight: 500;
    color: var(--color-gray-600);
    transition: all 0.2s ease;
}

.view-btn:hover {
    color: var(--color-gray-800);
    background: rgba(255, 255, 255, 0.5);
}

.view-btn.active {
    background: white;
    color: var(--color-primary);
    box-shadow: var(--shadow-sm);
}

.view-btn svg {
    flex-shrink: 0;
}

/* Grid View Styles */
.unified-grid-pagination {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 16px;
    margin-bottom: 24px;
    padding: 16px;
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
}

.grid-page-btn {
    padding: 10px 20px;
    border: 1px solid var(--color-gray-300);
    background: white;
    border-radius: var(--radius-md);
    cursor: pointer;
    font-size: 0.875rem;
    font-weight: 500;
    color: var(--color-gray-700);
    transition: all 0.2s ease;
}

.grid-page-btn:hover:not(:disabled) {
    background: var(--color-primary);
    color: white;
    border-color: var(--color-primary);
}

.grid-page-btn:disabled {
    opacity: 0.4;
    cursor: not-allowed;
}

.grid-page-info {
    font-size: 0.9rem;
    color: var(--color-gray-600);
}

.grid-page-info #currentPageNum {
    font-weight: 700;
    color: var(--color-primary);
    font-size: 1.1rem;
}

.grid-page-info .total-count {
    color: var(--color-gray-400);
    margin-left: 8px;
}

/* Grouped grid sections */
.grid-config-section {
    margin-bottom: 24px;
}

.grid-config-section:last-child {
    margin-bottom: 0;
}

.grid-section-header {
    display: flex;
    align-items: center;
    gap: 10px;
    margin-bottom: 16px;
    padding-bottom: 10px;
    border-bottom: 2px solid var(--color-gray-200);
}

.grid-section-header .pipeline-badge,
.grid-section-header .tool-badge {
    font-size: 0.75rem;
    padding: 4px 12px;
    border-radius: 6px;
    font-weight: 600;
}

.grid-section-header .pipeline-badge.colabdesign {
    background: rgba(16, 185, 129, 0.15);
    color: #059669;
}

.grid-section-header .pipeline-badge.rfd {
    background: rgba(245, 158, 11, 0.15);
    color: #d97706;
}

.grid-section-header .tool-badge.mpnn {
    background: rgba(59, 130, 246, 0.15);
    color: #2563eb;
}

.grid-section-header .tool-badge.triflow {
    background: rgba(168, 85, 247, 0.15);
    color: #9333ea;
}

.grid-section-header .section-count {
    color: var(--color-gray-500);
    font-size: 0.8rem;
    font-weight: normal;
    margin-left: auto;
}

.section-designs-grid {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: 16px;
}

@media (max-width: 1400px) {
    .section-designs-grid {
        grid-template-columns: repeat(3, 1fr);
    }
}

@media (max-width: 1000px) {
    .section-designs-grid {
        grid-template-columns: repeat(2, 1fr);
    }
}

@media (max-width: 600px) {
    .section-designs-grid {
        grid-template-columns: 1fr;
    }
}

.no-designs-message {
    text-align: center;
    padding: 60px;
    color: var(--color-gray-500);
    font-size: 1rem;
}

.grid-loading {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 12px;
    padding: 60px;
    color: var(--color-gray-500);
    font-size: 1rem;
}

.grid-loading .spinner {
    width: 24px;
    height: 24px;
    border: 3px solid var(--color-gray-200);
    border-top-color: var(--color-primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
}

/* Loading indicator for table */
.loading-indicator {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 12px;
    padding: 60px;
    color: var(--color-gray-500);
}

.loading-indicator .spinner {
    width: 24px;
    height: 24px;
    border: 3px solid var(--color-gray-200);
    border-top-color: var(--color-primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
}

.no-structures-message {
    text-align: center;
    padding: 60px;
    color: var(--color-gray-500);
}

/* Sequence count badge */
.sequence-count-badge {
    display: inline-block;
    background: var(--color-primary);
    color: white;
    font-size: 0.7rem;
    font-weight: 600;
    padding: 2px 8px;
    border-radius: 10px;
    min-width: 24px;
    text-align: center;
}

.sequence-count-indicator {
    margin-bottom: 6px;
}

/* More info text */
.more-info {
    color: var(--color-gray-500);
    font-size: 0.875rem;
}

.design-grid-card {
    background: var(--color-gray-50);
    border-radius: var(--radius-lg);
    overflow: hidden;
    border: 2px solid transparent;
    transition: all 0.3s ease;
}

.design-grid-card:hover {
    box-shadow: var(--shadow-lg);
    border-color: var(--color-primary);
}

.design-viewer {
    width: 100%;
    height: 200px;
    min-height: 200px;
    background: linear-gradient(135deg, #1a1a2e 0%, #16213e 100%);
    position: relative;
    overflow: hidden;
}

/* Ensure Molstar fills the container */
.design-viewer > div {
    width: 100% !important;
    height: 100% !important;
}

.design-viewer .loading-structure {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    color: var(--color-gray-400);
    font-size: 0.75rem;
    text-align: center;
    z-index: 5;
}

/* Fallback when viewer fails */
.design-viewer:empty::after {
    content: 'Loading...';
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    color: var(--color-gray-400);
    font-size: 0.75rem;
}

.design-viewer .loading-structure .spinner {
    width: 20px;
    height: 20px;
    border: 2px solid var(--color-gray-600);
    border-top-color: var(--color-primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
    margin: 0 auto 8px;
}

@keyframes spin {
    to { transform: rotate(360deg); }
}

a.design-grid-info {
    display: block;
    padding: 12px 16px;
    text-decoration: none;
    color: inherit;
    cursor: pointer;
}

a.design-grid-info:hover {
    background: var(--color-gray-100);
}

.design-grid-id {
    font-weight: 600;
    font-size: 0.8rem;
    color: var(--color-gray-800);
    margin-bottom: 8px;
    word-break: break-all;
}

.design-grid-metrics {
    display: flex;
    flex-wrap: wrap;
    gap: 8px;
}

.design-grid-metrics .metric {
    font-size: 0.7rem;
    color: var(--color-gray-600);
    background: white;
    padding: 2px 8px;
    border-radius: 4px;
}

.design-grid-metrics .metric strong {
    color: var(--color-gray-800);
}

/* View content transitions */
.view-content {
    transition: opacity 0.2s ease;
}

.view-content.hidden {
    display: none !important;
}


/* design_detail.html style block 1 */
.design-badges {
    display: flex;
    gap: 8px;
    margin-top: 8px;
}

.pdb-description-header {
    color: var(--color-gray-600);
    font-size: 1rem;
    margin: 8px 0 4px 0;
    font-weight: 400;
    max-width: 800px;
}

/* Metrics Row (Top) */
.metrics-row {
    margin-bottom: 20px;
}

.metrics-panel-horizontal {
    display: flex;
    gap: 24px;
    background: white;
    padding: 16px 24px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    flex-wrap: wrap;
}

.info-section-inline {
    display: flex;
    flex-direction: column;
    gap: 8px;
    padding-right: 24px;
    border-right: 1px solid var(--color-gray-100);
}

.info-section-inline:last-child {
    border-right: none;
    padding-right: 0;
}

.info-section-inline h3 {
    font-size: 0.7rem;
    font-weight: 600;
    color: var(--color-gray-500);
    text-transform: uppercase;
    margin: 0;
    letter-spacing: 0.02em;
}

.info-grid-inline {
    display: flex;
    gap: 16px;
}

.info-grid-inline .info-item {
    display: flex;
    flex-direction: column;
    gap: 2px;
    padding: 6px 10px;
    background: var(--color-gray-50);
    border-radius: var(--radius-sm);
}

.info-grid-inline .info-item .label {
    font-size: 0.65rem;
    color: var(--color-gray-500);
}

.info-grid-inline .info-item .value {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--color-gray-800);
}

.metrics-grid-inline {
    display: flex;
    gap: 8px;
}

.metric-card-inline {
    text-align: center;
    padding: 6px 12px;
    background: var(--color-gray-50);
    border-radius: var(--radius-sm);
    min-width: 50px;
}

.metric-card-inline .metric-value {
    font-size: 1rem;
    font-weight: 700;
    color: var(--color-gray-800);
}

.metric-card-inline .metric-value.good {
    color: var(--color-success);
}

.metric-card-inline .metric-value.medium {
    color: var(--color-warning);
}

.metric-card-inline .metric-label {
    font-size: 0.6rem;
    color: var(--color-gray-500);
    margin-top: 2px;
}

@media (max-width: 1200px) {
    .metrics-panel-horizontal {
        gap: 16px;
    }
    .info-section-inline {
        padding-right: 16px;
    }
}

@media (max-width: 900px) {
    .metrics-panel-horizontal {
        flex-direction: column;
        gap: 12px;
    }
    .info-section-inline {
        border-right: none;
        padding-right: 0;
        padding-bottom: 12px;
        border-bottom: 1px solid var(--color-gray-100);
    }
    .info-section-inline:last-child {
        border-bottom: none;
        padding-bottom: 0;
    }
}

/* Viewers Grid (PAE + Structure) */
.viewers-grid {
    display: grid;
    grid-template-columns: 450px 1fr;
    gap: 16px;
    margin-bottom: 12px;
    align-items: start;
}

@media (max-width: 1000px) {
    .viewers-grid {
        grid-template-columns: 1fr;
    }
}

/* PAE Column (Left) */
.pae-column {
    background: white;
    padding: 14px;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
}

.pae-panel-standalone {
}

.pae-canvas-container {
    position: relative;
    width: 100%;
}

#pae-canvas {
    width: 100%;
    height: auto;
    cursor: crosshair;
    border: 1px solid var(--color-gray-200);
    border-radius: var(--radius-sm);
}

.structure-panel {
    background: white;
    padding: 14px;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
    display: flex;
    flex-direction: column;
}

.molstar-viewer-container {
    width: 100%;
    height: 320px;
    position: relative;
    background: linear-gradient(135deg, #1a1a2e 0%, #16213e 100%);
    border-radius: var(--radius-md);
    overflow: hidden;
}

.molstar-viewer-container.molstar-square {
    flex: 1;
    min-height: 400px;
}

/* Molstar sequence panel styling */
.molstar-viewer-container .msp-sequence-wrapper {
    min-height: 80px !important;
    max-height: 120px !important;
}

.molstar-viewer-container .msp-plugin {
    height: 100% !important;
}

/* Hide Molstar sidebar/left panel on all viewers */
.molstar-viewer-container .msp-layout-left,
.molstar-viewer-container .msp-left-panel-controls,
.molstar-viewer-container .msp-layout-collapse-left,
.molstar-viewer-container .msp-viewport-controls-panel,
.molstar-viewer-container .msp-viewport-top-left-controls,
.molstar-viewer-container [class*="msp-layout-left"],
.molstar-viewer-container [class*="left-panel"] {
    display: none !important;
    width: 0 !important;
    min-width: 0 !important;
    max-width: 0 !important;
    visibility: hidden !important;
    opacity: 0 !important;
    pointer-events: none !important;
}

/* Force left region to have no width */
.molstar-viewer-container .msp-layout-region[class*="left"] {
    display: none !important;
    width: 0 !important;
}

/* Ensure main viewport takes full width */
.molstar-viewer-container .msp-layout-main {
    left: 0 !important;
}

/* Hide viewport controls (zoom, reset, orient buttons) */
.molstar-viewer-container .msp-viewport-controls,
.molstar-viewer-container .msp-viewport-controls-buttons,
.molstar-viewer-container .msp-viewport-controls-panel,
.molstar-viewer-container .msp-viewport-controls-panel-controls,
.molstar-viewer-container .msp-viewport-top-left-controls {
    display: none !important;
    visibility: hidden !important;
}

/* Structure label for native view */
.structure-label {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 8px;
}

.structure-label .label-badge.native {
    background: rgba(16, 185, 129, 0.9);
    color: white;
    padding: 4px 12px;
    border-radius: 20px;
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
}

.structure-label .target-name {
    background: rgba(0, 0, 0, 0.7);
    color: white;
    padding: 4px 12px;
    border-radius: 20px;
    font-size: 0.75rem;
    font-weight: 500;
}

/* Compare color toggle */
.compare-color-toggle {
    position: absolute;
    top: 40px;
    left: 12px;
    z-index: 10;
    margin-bottom: 0;
}

.compare-color-toggle button {
    padding: 2px 8px;
    font-size: 0.65rem;
}

/* Color Scheme Toggle */
.color-scheme-toggle {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 8px;
}

.color-scheme-toggle button {
    padding: 4px 10px;
    border-radius: 4px;
    border: 1px solid var(--color-gray-300);
    background: var(--color-gray-100);
    font-size: 0.75rem;
    cursor: pointer;
    transition: all 0.2s;
}

.color-scheme-toggle button:hover {
    background: var(--color-gray-200);
}

.btn-plddt,
.btn-chain {
    background: #ffffff !important;
    color: var(--color-gray-600) !important;
    border: 1px solid var(--color-gray-300) !important;
}

.btn-plddt:not(.active):hover,
.btn-chain:not(.active):hover {
    border-color: var(--color-primary) !important;
    color: var(--color-primary) !important;
    background: #ffffff !important;
}

.btn-plddt.active,
.btn-chain.active {
    background: var(--color-primary) !important;
    border-color: var(--color-primary) !important;
    color: white !important;
}

/* pLDDT Legend */
.plddt-legend {
    display: flex;
    gap: 8px;
    flex-wrap: wrap;
    margin-top: 8px;
    font-size: 0.65rem;
}

.plddt-legend-item {
    display: flex;
    align-items: center;
    gap: 3px;
}

.plddt-legend-color {
    width: 12px;
    height: 12px;
    border-radius: 2px;
}

/* PAE Panel Styles */
.pae-header {
    font-size: 0.85rem;
    font-weight: 600;
    margin-bottom: 8px;
    color: var(--color-gray-700);
}

.pae-legend {
    display: flex;
    align-items: center;
    gap: 6px;
    margin-top: 8px;
    font-size: 0.7rem;
    color: var(--color-gray-600);
}

.pae-legend-bar {
    flex: 1;
    height: 12px;
    background: linear-gradient(90deg, #0053d6 0%, #65cbf3 25%, #ffdb13 50%, #ff7d45 75%, #ff0000 100%);
    border-radius: 2px;
}

.pae-info {
    margin-top: 8px;
    padding: 8px;
    background: var(--color-gray-50);
    border-radius: var(--radius-sm);
    font-size: 0.75rem;
    color: var(--color-gray-700);
    min-height: 50px;
}


.viewer-controls {
    display: flex;
    gap: 16px;
    margin-top: 16px;
    flex-wrap: wrap;
    align-items: center;
}

.viewer-controls .btn.active {
    background: var(--color-primary);
    color: white;
    border-color: var(--color-primary);
}

.no-structure {
    padding: 80px;
    text-align: center;
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
    color: var(--color-gray-500);
}

.info-section {
    margin-bottom: 24px;
    padding-bottom: 24px;
    border-bottom: 1px solid var(--color-gray-100);
}

.info-section:last-child {
    border-bottom: none;
    margin-bottom: 0;
    padding-bottom: 0;
}

.pdb-description {
    margin-top: 16px;
    padding: 12px 16px;
    background: linear-gradient(135deg, var(--color-gray-50), #f0f9ff);
    border-radius: var(--radius-md);
    border-left: 3px solid var(--color-primary);
}

.pdb-description .label {
    font-weight: 600;
    color: var(--color-gray-600);
    font-size: 0.8rem;
    text-transform: uppercase;
    display: block;
    margin-bottom: 4px;
}

.pdb-description .description-text {
    color: var(--color-gray-800);
    font-size: 0.95rem;
    line-height: 1.4;
}

.info-section h3 {
    font-size: 0.875rem;
    font-weight: 600;
    color: var(--color-gray-600);
    text-transform: uppercase;
    margin-bottom: 16px;
}

.info-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 12px;
}

.info-item {
    display: flex;
    justify-content: space-between;
    padding: 8px 12px;
    background: var(--color-gray-50);
    border-radius: var(--radius-sm);
}

.info-item .label {
    color: var(--color-gray-500);
    font-size: 0.875rem;
}

.info-item .value {
    font-weight: 600;
    color: var(--color-gray-800);
}

.info-item .value a {
    color: var(--color-primary);
    text-decoration: none;
}

.info-item .value .pdb-link {
    display: inline-flex;
    align-items: center;
    margin-left: 6px;
    padding: 2px 4px;
    color: var(--color-gray-500);
    border-radius: 4px;
    transition: all 0.2s ease;
}

.info-item .value .pdb-link:hover {
    color: var(--color-primary);
    background: rgba(59, 130, 246, 0.1);
}

.metrics-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 16px;
}

.metric-card {
    text-align: center;
    padding: 16px;
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
}

.metric-card .metric-value {
    font-size: 1.5rem;
    font-weight: 700;
    color: var(--color-gray-800);
}

.metric-card .metric-value.good {
    color: var(--color-success);
}

.metric-card .metric-value.medium {
    color: var(--color-warning);
}

.metric-card .metric-label {
    font-size: 0.75rem;
    color: var(--color-gray-500);
    margin-top: 4px;
}

/* Native Sequence Section */
.native-sequence-section {
    background: white;
    padding: 16px 20px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-bottom: 16px;
}

.native-sequence-header {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 10px;
    padding-bottom: 8px;
    border-bottom: 1px solid var(--color-gray-100);
}

.native-sequence-header h2 {
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--color-gray-800);
    margin: 0;
}

.native-sequence-subtitle {
    font-size: 0.75rem;
    color: var(--color-gray-500);
}

.native-sequence-container {
    overflow: hidden;
}

.native-sequence-container .msa-canvas-wrapper {
    max-height: none;
}

.native-sequence-container .msa-label-row.native-label {
    cursor: default;
}

.native-sequence-container .msa-label-row.native-label:hover {
    background-color: var(--color-gray-100);
}

.native-sequence-container .msa-seq-row.native-seq {
    cursor: default;
}

.native-sequence-container .msa-seq-row.native-seq:hover {
    background-color: transparent;
}

.native-sequence-loading {
    color: var(--color-gray-500);
    font-style: italic;
    padding: 12px;
}

.actions-section {
    display: flex;
    gap: 12px;
    flex-wrap: wrap;
}

/* Structure Tabs */
.structure-tabs {
    display: flex;
    gap: 4px;
    margin-bottom: 16px;
    background: var(--color-gray-100);
    padding: 4px;
    border-radius: var(--radius-md);
}

.structure-tab {
    flex: 1;
    padding: 10px 16px;
    border: none;
    background: transparent;
    border-radius: var(--radius-sm);
    cursor: pointer;
    font-size: 0.875rem;
    font-weight: 500;
    color: var(--color-gray-600);
    transition: all 0.2s ease;
}

.structure-tab:hover {
    color: var(--color-gray-800);
    background: rgba(255, 255, 255, 0.5);
}

.structure-tab.active {
    background: white;
    color: var(--color-primary);
    box-shadow: var(--shadow-sm);
}

.structure-viewer-wrapper {
    position: relative;
    flex: 1;
    display: flex;
    flex-direction: column;
}

.native-structure-label {
    position: absolute;
    top: 12px;
    left: 12px;
    z-index: 10;
    display: flex;
    align-items: center;
    gap: 8px;
}

.label-badge {
    background: rgba(16, 185, 129, 0.9);
    color: white;
    padding: 4px 12px;
    border-radius: 20px;
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.02em;
}

.target-name {
    background: rgba(0, 0, 0, 0.7);
    color: white;
    padding: 4px 12px;
    border-radius: 20px;
    font-size: 0.75rem;
    font-weight: 500;
}

/* Compare View */
.compare-view .compare-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 16px;
}

.compare-panel {
    position: relative;
}

.compare-label {
    position: absolute;
    top: 12px;
    left: 12px;
    z-index: 10;
    background: rgba(0, 0, 0, 0.7);
    color: white;
    padding: 4px 12px;
    border-radius: 20px;
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
}

.compare-viewer {
    aspect-ratio: 1 / 1 !important;
    height: auto !important;
    max-height: 400px;
}

@media (max-width: 800px) {
    .compare-view .compare-grid {
        grid-template-columns: 1fr;
    }

    .compare-viewer {
        max-height: 350px;
    }
}

/* MSA Viewer Styles */
.msa-section {
    background: white;
    padding: 16px 20px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-bottom: 16px;
}

.msa-section .msa-header {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 12px;
    padding-bottom: 8px;
    border-bottom: 1px solid var(--color-gray-100);
}

.msa-section .msa-header h2 {
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--color-gray-800);
    margin: 0;
    white-space: nowrap;
}

.msa-subtitle {
    font-size: 0.75rem;
    color: var(--color-gray-500);
    white-space: nowrap;
}

.msa-mode-options {
    display: flex;
    align-items: center;
    gap: 4px;
    margin-left: 12px;
}

.msa-mode-btn {
    padding: 5px 12px;
    font-size: 0.75rem;
    font-weight: 600;
    border: 1px solid var(--color-gray-300);
    background: white;
    color: var(--color-gray-600);
    border-radius: 4px;
    cursor: pointer;
    transition: all 0.15s ease;
}

.msa-mode-btn:hover {
    border-color: var(--color-primary);
    color: var(--color-primary);
}

.msa-mode-btn.active {
    background: var(--color-primary);
    border-color: var(--color-primary);
    color: white;
}

.msa-color-options,
.logo-bit-options {
    margin-left: auto;
    display: flex;
    align-items: center;
    gap: 6px;
}

.msa-color-options .color-label {
    font-size: 0.75rem;
    color: var(--color-gray-500);
    margin-right: 4px;
}

.msa-color-btn {
    padding: 4px 10px;
    font-size: 0.7rem;
    font-weight: 500;
    border: 1px solid var(--color-gray-300);
    background: white;
    color: var(--color-gray-600);
    border-radius: 4px;
    cursor: pointer;
    transition: all 0.15s ease;
}

.msa-color-btn:hover {
    border-color: var(--color-primary);
    color: var(--color-primary);
}

.msa-color-btn.active {
    background: var(--color-primary);
    border-color: var(--color-primary);
    color: white;
}

.msa-chain-options {
    display: flex;
    align-items: center;
    gap: 6px;
}

.msa-chain-btn {
    padding: 4px 10px;
    font-size: 0.7rem;
    font-weight: 500;
    border: 1px solid var(--color-gray-300);
    background: white;
    color: var(--color-gray-600);
    border-radius: 4px;
    cursor: pointer;
    transition: all 0.15s ease;
}

.msa-chain-btn:hover {
    border-color: var(--color-primary);
    color: var(--color-primary);
}

.msa-chain-btn.active {
    background: var(--color-primary);
    border-color: var(--color-primary);
    color: white;
}

.pssm-container,
.logo-container {
    background: white;
    border-radius: var(--radius-md);
    overflow-x: auto;
    padding: 16px;
}

.pssm-container canvas,
.logo-container canvas {
    display: block;
}

.msa-container {
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
    overflow: hidden;
}

.msa-loading {
    padding: 40px;
    text-align: center;
    color: var(--color-gray-500);
}

.msa-canvas-wrapper {
    display: flex;
    max-height: 400px;
    overflow: hidden;
}

.msa-labels-column {
    flex: 0 0 220px;
    overflow-y: auto;
    background: var(--color-gray-100);
    border-right: 2px solid var(--color-gray-300);
}

.msa-sequences-column {
    flex: 1;
    overflow: auto;
}

.msa-label-row {
    padding: 6px 12px;
    font-size: 0.75rem;
    font-family: monospace;
    color: var(--color-gray-700);
    background: var(--color-gray-100);
    display: flex;
    flex-direction: column;
    justify-content: center;
    gap: 2px;
    height: 44px;
    box-sizing: border-box;
    border-bottom: 1px solid var(--color-gray-200);
    cursor: pointer;
    transition: background-color 0.15s ease;
}

.msa-label-row:hover {
    background-color: rgba(59, 130, 246, 0.1);
}

.msa-label-row.active {
    background-color: rgba(59, 130, 246, 0.15);
}

.msa-label-row.current {
    background-color: rgba(16, 185, 129, 0.15);
}

.msa-label-row .design-name {
    font-weight: 600;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
}

.msa-label-row .design-metrics {
    font-size: 0.65rem;
    color: var(--color-gray-500);
}

.msa-seq-row {
    display: flex;
    align-items: center;
    padding: 6px 12px;
    font-family: 'Courier New', monospace;
    font-size: 0.8rem;
    letter-spacing: 0.02em;
    white-space: nowrap;
    height: 44px;
    box-sizing: border-box;
    border-bottom: 1px solid var(--color-gray-200);
    cursor: pointer;
    transition: background-color 0.15s ease;
}

.msa-seq-row:hover {
    background-color: rgba(59, 130, 246, 0.05);
}

.msa-seq-row.active {
    background-color: rgba(59, 130, 246, 0.1);
}

.msa-seq-row.current {
    background-color: rgba(16, 185, 129, 0.1);
}

.msa-residue {
    display: inline-block;
    width: 14px;
    text-align: center;
    padding: 2px 0;
    border-radius: 2px;
}

/* Amino acid coloring (Clustal-like) */
.msa-residue.hydrophobic { background-color: #80a0f0; color: white; }  /* A, I, L, M, F, W, V */
.msa-residue.positive { background-color: #f01505; color: white; }     /* K, R */
.msa-residue.negative { background-color: #c048c0; color: white; }     /* D, E */
.msa-residue.polar { background-color: #15c015; color: white; }        /* N, Q, S, T */
.msa-residue.cysteine { background-color: #f08080; color: white; }     /* C */
.msa-residue.glycine { background-color: #f09048; color: white; }      /* G */
.msa-residue.proline { background-color: #c0c000; color: black; }      /* P */
.msa-residue.aromatic { background-color: #15a4a4; color: white; }     /* H, Y */
.msa-residue.gap { background-color: transparent; color: #ccc; }       /* - */

.msa-chain-separator {
    display: inline-block;
    width: 20px;
    text-align: center;
    font-weight: bold;
    color: var(--color-gray-400);
    font-size: 1rem;
}

.msa-no-structure {
    opacity: 0.5;
}

.msa-current-badge {
    display: inline-block;
    background: var(--color-success);
    color: white;
    font-size: 0.6rem;
    padding: 1px 4px;
    border-radius: 3px;
    margin-left: 4px;
    text-transform: uppercase;
    font-weight: 600;
}

/* Sequence Viewer Styles */
.sequence-viewer-section {
    background: white;
    padding: 16px 20px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-bottom: 16px;
}

.sequence-viewer-header {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 10px;
    padding-bottom: 8px;
    border-bottom: 1px solid var(--color-gray-100);
    flex-wrap: wrap;
}

.sequence-viewer-header h2 {
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--color-gray-800);
    margin: 0;
}

.sequence-viewer-subtitle {
    font-size: 0.75rem;
    color: var(--color-gray-500);
}

.sequence-actions {
    display: flex;
    gap: 4px;
    align-items: center;
    margin-left: auto;
}

.sequence-info {
    font-size: 0.7rem;
    color: var(--color-gray-500);
    margin-left: 12px;
}

.btn-copy {
    padding: 3px 8px !important;
    font-size: 0.65rem !important;
    background: #6c757d !important;
    color: white !important;
    border: none !important;
    border-radius: 3px !important;
    cursor: pointer;
}

.btn-copy:hover {
    background: #5a6268 !important;
}

.sequence-viewer-container {
    overflow-x: auto;
    padding: 5px 0;
}

.sequence-row {
    display: flex;
    align-items: center;
    gap: 8px;
    white-space: nowrap;
    margin-bottom: 4px;
}

.sequence-label {
    font-weight: bold;
    font-size: 0.7rem;
    min-width: 60px;
}

.chain-a-label { color: #e74c3c; }
.chain-b-label { color: #3498db; }

.sequence-residues {
    display: flex;
    font-family: 'Courier New', monospace;
    font-size: 10px;
}

.sequence-residue {
    width: 12px;
    height: 16px;
    display: flex;
    align-items: center;
    justify-content: center;
    cursor: pointer;
    border-radius: 2px;
    transition: background-color 0.1s;
}

.sequence-residue:hover {
    background-color: #e0e0e0;
}

.sequence-residue.highlighted {
    background-color: #00d4aa;
    color: white;
}

.sequence-residue.selected {
    background-color: #3498db;
    color: white;
    font-weight: bold;
}

.sequence-ruler {
    display: flex;
    font-family: 'Courier New', monospace;
    font-size: 8px;
    color: #999;
    margin-left: 68px;
    margin-bottom: 2px;
}

.sequence-ruler-mark {
    width: 12px;
    text-align: center;
}

.seq-color-options {
    display: flex;
    align-items: center;
    gap: 4px;
    margin-left: 12px;
}

.seq-color-options .color-label {
    font-size: 0.7rem;
    color: var(--color-gray-500);
    margin-right: 2px;
}

.seq-color-btn {
    padding: 3px 8px;
    font-size: 0.65rem;
    font-weight: 500;
    border: 1px solid var(--color-gray-300);
    background: white;
    color: var(--color-gray-600);
    border-radius: 4px;
    cursor: pointer;
    transition: all 0.15s ease;
}

.seq-color-btn:hover {
    border-color: var(--color-primary);
    color: var(--color-primary);
}

.seq-color-btn.active {
    background: var(--color-primary);
    border-color: var(--color-primary);
    color: white;
}

/* Amino acid coloring by type (Clustal-like - same as MSA viewer) */
.sequence-residue.aa-hydrophobic { background-color: #80a0f0; color: white; }
.sequence-residue.aa-positive { background-color: #f01505; color: white; }
.sequence-residue.aa-negative { background-color: #c048c0; color: white; }
.sequence-residue.aa-polar { background-color: #15c015; color: white; }
.sequence-residue.aa-cysteine { background-color: #f08080; color: white; }
.sequence-residue.aa-glycine { background-color: #f09048; color: white; }
.sequence-residue.aa-proline { background-color: #c0c000; color: black; }
.sequence-residue.aa-aromatic { background-color: #15a4a4; color: white; }

/* Amino acid coloring by charge (same as MSA viewer) */
.sequence-residue.charge-positive { background-color: #3b82f6; color: white; }
.sequence-residue.charge-negative { background-color: #ef4444; color: white; }
.sequence-residue.charge-neutral { background-color: #f3f4f6; color: #374151; }


/* structure_detail.html style block 1 */
.structure-detail {
    max-width: 1600px;
    margin: 0 auto;
}

.back-link {
    color: var(--color-gray-500);
    text-decoration: none;
    font-size: 0.875rem;
}

.back-link:hover {
    color: var(--color-primary);
}

/* Main two-column grid layout */
.main-content-grid {
    display: grid;
    grid-template-columns: 400px 1fr;
    gap: 24px;
    align-items: start;
}

@media (max-width: 1200px) {
    .main-content-grid {
        grid-template-columns: 1fr;
    }
}

/* Structure viewer - fixed height, sticky on scroll */
.structure-viewer-section {
    background: white;
    padding: 16px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    position: sticky;
    top: 20px;
}

.viewer-header {
    margin-bottom: 8px;
}

.viewer-header h2 {
    margin: 0;
    font-size: 1.1rem;
}

.current-sequence-label {
    font-size: 0.8rem;
    color: var(--color-gray-600);
    margin-bottom: 12px;
    padding: 6px 10px;
    background: var(--color-gray-50);
    border-radius: var(--radius-sm);
    word-break: break-all;
}

.current-sequence-label strong {
    color: var(--color-primary);
}

.molstar-viewer-container {
    height: 350px;
    border-radius: var(--radius-md);
    overflow: hidden;
}

.no-structure-message {
    padding: 40px;
    text-align: center;
    color: var(--color-gray-500);
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
    height: 350px;
    display: flex;
    align-items: center;
    justify-content: center;
}

/* Sequences container */
.sequences-container {
    display: flex;
    flex-direction: column;
    gap: 20px;
}

.sequences-section {
    background: white;
    padding: 16px;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.sequences-section.mpnn-section {
    border-left: 4px solid var(--color-mpnn);
}

.sequences-section.triflow-section {
    border-left: 4px solid var(--color-triflow);
}

.section-header {
    margin-bottom: 12px;
}

.section-header h2 {
    display: flex;
    align-items: center;
    gap: 10px;
    margin: 0;
    font-size: 1rem;
}

/* MSA Container */
.msa-container {
    margin-bottom: 16px;
    border: 1px solid var(--color-gray-200);
    border-radius: var(--radius-md);
    overflow: hidden;
}

/* Sequences table - more compact */
.sequences-table {
    max-height: 300px;
    overflow-y: auto;
}

.sequences-data-table {
    font-size: 0.8rem;
}

.sequences-data-table th,
.sequences-data-table td {
    padding: 8px 10px;
}

/* MSA Viewer Styles */
.msa-header {
    display: flex;
    align-items: center;
    padding: 10px 16px;
    background: var(--color-gray-50);
    border-bottom: 1px solid var(--color-gray-200);
}

.msa-mode-btn {
    padding: 4px 12px;
    border: 1px solid var(--color-gray-300);
    background: white;
    border-radius: 4px;
    cursor: pointer;
    font-size: 0.75rem;
    transition: all 0.2s ease;
}

.msa-mode-btn:hover {
    background: var(--color-gray-100);
}

.msa-mode-btn.active {
    background: var(--color-primary);
    color: white;
    border-color: var(--color-primary);
}

.msa-canvas {
    display: block;
}

.sequence-row {
    cursor: pointer;
    transition: background-color 0.2s ease;
}

.sequence-row:hover {
    background-color: var(--color-gray-50);
}

.sequence-row.active {
    background-color: rgba(59, 130, 246, 0.1);
}

.sequence-row.active td {
    font-weight: 500;
}

.design-id-cell {
    max-width: 200px;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
    font-size: 0.75rem;
}

.no-pdb-label {
    color: var(--color-gray-400);
    font-size: 0.75rem;
}

.load-structure-btn {
    white-space: nowrap;
}

/* Tool badges */
.tool-badge {
    display: inline-block;
    padding: 4px 12px;
    border-radius: 6px;
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
}

.tool-badge.mpnn {
    background: rgba(59, 130, 246, 0.15);
    color: #2563eb;
}

.tool-badge.triflow {
    background: rgba(168, 85, 247, 0.15);
    color: #9333ea;
}

.pipeline-badge {
    display: inline-block;
    padding: 4px 12px;
    border-radius: 6px;
    font-size: 0.75rem;
    font-weight: 600;
}

.pipeline-badge.colabdesign {
    background: rgba(16, 185, 129, 0.15);
    color: #059669;
}

.pipeline-badge.rfd {
    background: rgba(245, 158, 11, 0.15);
    color: #d97706;
}


/* cytokines.html style block 1 */
.cytokines-page {
    width: 100%;
}

/* Legend Styles */
.heatmap-legend {
    background: white;
    padding: 4px 12px;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
    margin-bottom: 3px;
    display: flex;
    align-items: center;
    gap: 12px;
    flex-wrap: wrap;
    font-size: 0.8rem;
}

.legend-label {
    font-weight: 600;
    color: var(--color-gray-700);
}

.legend-scale {
    display: flex;
    align-items: center;
    gap: 8px;
}

.legend-min, .legend-max {
    font-size: 0.75rem;
    color: var(--color-gray-500);
}

.legend-gradient-container {
    display: flex;
    flex-direction: column;
    align-items: center;
}

.legend-gradient {
    width: 150px;
    height: 12px;
    background: linear-gradient(to right,
        #006400 0%,
        #4caf50 50%,
        #ffffff 100%
    );
    border-radius: 3px;
    border: 1px solid var(--color-gray-300);
}

.legend-values {
    display: flex;
    width: 150px;
    justify-content: space-between;
    font-size: 0.65rem;
    color: var(--color-gray-500);
    margin-bottom: 2px;
}

.cytokines-page .page-header {
    margin-bottom: 3px;
}

/* Introduction section */
.intro-section {
    margin-bottom: 3px;
    padding: 10px 16px;
    background: var(--color-gray-50);
    border-radius: var(--radius-md);
}

.intro-content p {
    margin: 0;
    color: var(--color-gray-700);
    line-height: 1.5;
    font-size: 0.875rem;
}

.intro-content strong {
    color: var(--color-gray-900);
}

/* Main Content Layout */
.cytokines-content {
    display: grid;
    grid-template-columns: max-content minmax(680px, 1fr);
    gap: 10px;
    align-items: start;
    height: calc(100vh - 180px);
    min-height: 540px;
}

@media (max-width: 1500px) {
    .cytokines-content {
        grid-template-columns: max-content minmax(560px, 1fr);
    }
}

@media (max-width: 1100px) {
    .detail-panel {
        position: fixed;
        top: 0;
        right: 0;
        height: 100vh;
        width: 800px;
        max-width: 90vw;
        z-index: 1000;
        transform: translateX(100%);
        transition: transform 0.3s ease;
    }

    .detail-panel.active {
        transform: translateX(0);
    }
}

/* Heatmap Section */
.heatmap-section {
    background: white;
    padding: 6px;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
    overflow: auto;
    height: 100%;
    min-width: 0;
}

.heatmap-container {
    width: max-content;
    min-width: 100%;
}

/* Heatmap Table - Compact version */
.heatmap-table {
    border-collapse: separate;
    border-spacing: 1px;
    font-size: 0.58rem;
}

.heatmap-table th {
    padding: 3px 4px;
    background: var(--color-gray-100);
    font-weight: 600;
    position: sticky;
    z-index: 10;
}

.heatmap-table th.corner {
    top: 0;
    left: 0;
    z-index: 20;
    background: var(--color-gray-200);
}

.heatmap-table th.col-header {
    top: 0;
    writing-mode: vertical-rl;
    text-orientation: mixed;
    transform: rotate(180deg);
    white-space: nowrap;
    height: 44px;
    vertical-align: bottom;
    font-size: 0.5rem;
}

.heatmap-table th.row-header {
    left: 0;
    text-align: right;
    white-space: nowrap;
    font-size: 0.5rem;
}

.heatmap-table td {
    width: 10px;
    height: 10px;
    padding: 0;
    text-align: center;
    cursor: pointer;
    transition: all 0.15s ease;
    position: relative;
    border: 1px solid #000;
}

.heatmap-table td:hover {
    outline: 2px solid var(--color-gray-900);
    outline-offset: -1px;
    z-index: 5;
}

.heatmap-table td.selected {
    outline: 3px solid var(--color-primary);
    outline-offset: -1px;
    z-index: 6;
}

.heatmap-table td.no-data {
    background: var(--color-gray-100);
    cursor: default;
}

.heatmap-table td.no-data:hover {
    outline: none;
}

/* Tooltip for heatmap cells */
.heatmap-tooltip {
    position: fixed;
    background: rgba(0, 0, 0, 0.85);
    color: white;
    padding: 6px 10px;
    border-radius: 4px;
    font-size: 0.75rem;
    pointer-events: none;
    z-index: 1000;
    white-space: nowrap;
    box-shadow: 0 2px 8px rgba(0,0,0,0.3);
}

.heatmap-tooltip .tooltip-title {
    font-weight: 600;
    margin-bottom: 2px;
}

.heatmap-tooltip .tooltip-value {
    color: #4fa6f5;
}

/* Detail Panel */
.detail-panel {
    background: white;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
    overflow: hidden;
    height: 100%;
    min-width: 0;
    position: sticky;
    top: 72px;
}

.detail-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 8px 12px;
    background: var(--color-gray-50);
    border-bottom: 1px solid var(--color-gray-200);
}

.detail-header h2 {
    margin: 0;
    font-size: 0.9rem;
}

.close-btn {
    background: none;
    border: none;
    font-size: 1.5rem;
    cursor: pointer;
    color: var(--color-gray-500);
    padding: 0;
    line-height: 1;
}

.close-btn:hover {
    color: var(--color-gray-900);
}

.detail-content {
    padding: 8px;
    max-height: calc(100% - 48px);
    overflow-y: auto;
}

.placeholder-message {
    color: var(--color-gray-500);
    text-align: center;
    padding: 20px 12px;
    font-size: 0.85rem;
}

/* Info Section */
.info-grid {
    display: flex;
    gap: 8px;
    margin-bottom: 8px;
}

.info-item {
    background: var(--color-gray-50);
    padding: 6px 10px;
    border-radius: var(--radius-sm);
    display: flex;
    align-items: center;
    gap: 6px;
}

.info-item .label {
    font-size: 0.7rem;
    color: var(--color-gray-500);
    text-transform: uppercase;
    letter-spacing: 0.03em;
}

.info-item .value {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--color-gray-900);
}

.info-item .value.good {
    color: #059669;
}

.info-item .value.medium {
    color: #d97706;
}

.info-item .value.poor {
    color: #dc2626;
}

/* Viewer Layout */
.viewer-layout {
    display: grid;
    grid-template-columns: minmax(320px, 420px) minmax(360px, 1fr);
    gap: 12px;
    margin-bottom: 12px;
    align-items: start;
}

.molstar-panel {
    min-width: 0;
    display: flex;
    flex-direction: column;
}

.pae-panel {
    width: 100%;
    min-width: 0;
    display: flex;
    flex-direction: column;
}

/* Molstar Container */
.molstar-container {
    height: 420px;
    border-radius: var(--radius-md);
    overflow: hidden;
    background: linear-gradient(135deg, #1a1a2e 0%, #16213e 100%);
    position: relative;
}

#molstar-viewer {
    width: 100%;
    height: 100%;
}

.color-scheme-toggle {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: 8px;
}

.color-scheme-toggle button {
    padding: 4px 10px;
    border-radius: 4px;
    border: 1px solid var(--color-gray-300);
    background: var(--color-gray-100);
    font-size: 0.75rem;
    cursor: pointer;
    transition: background 0.2s;
}

.color-scheme-toggle button:hover {
    background: var(--color-gray-200);
}

.btn-plddt,
.btn-chain {
    background: #ffffff !important;
    color: var(--color-gray-600) !important;
    border: 1px solid var(--color-gray-300) !important;
}

.btn-plddt:not(.active):hover,
.btn-chain:not(.active):hover {
    border-color: var(--color-primary) !important;
    color: var(--color-primary) !important;
    background: #ffffff !important;
}

.btn-plddt.active,
.btn-chain.active {
    background: var(--color-primary) !important;
    border-color: var(--color-primary) !important;
    color: white !important;
}

.btn-save {
    background: #ffffff !important;
    color: var(--color-gray-600) !important;
    border: 1px solid var(--color-gray-300) !important;
}

.btn-save:hover {
    border-color: var(--color-primary) !important;
    color: var(--color-primary) !important;
    background: #ffffff !important;
}

.btn-copy {
    padding: 3px 8px !important;
    font-size: 0.65rem !important;
    background: #6c757d !important;
    color: white !important;
    border: none !important;
    border-radius: 3px !important;
}

.btn-copy:hover {
    background: #5a6268 !important;
}

/* PAE Matrix */
.pae-header {
    font-size: 0.85rem;
    font-weight: 600;
    margin-bottom: 8px;
    color: var(--color-gray-700);
}

.pae-canvas-container {
    position: relative;
    width: 100%;
    height: 420px;
}

#pae-canvas {
    width: 100%;
    height: 100%;
    display: block;
    object-fit: contain;
    cursor: crosshair;
    border: 1px solid var(--color-gray-200);
    border-radius: var(--radius-sm);
}

@media (max-width: 1300px) {
    .viewer-layout {
        grid-template-columns: 1fr;
    }
}

.pae-info {
    margin-top: 8px;
    padding: 8px;
    background: var(--color-gray-50);
    border-radius: var(--radius-sm);
    font-size: 0.75rem;
    color: var(--color-gray-700);
    min-height: 50px;
}

.pae-legend {
    display: flex;
    align-items: center;
    gap: 6px;
    margin-top: 8px;
    font-size: 0.7rem;
    color: var(--color-gray-600);
}

.pae-legend-bar {
    flex: 1;
    height: 12px;
    background: linear-gradient(90deg, #0053d6 0%, #65cbf3 25%, #ffdb13 50%, #ff7d45 75%, #ff0000 100%);
    border-radius: 2px;
}

/* Sequence Viewer */
.sequence-panel {
    border-top: 1px solid var(--color-gray-200);
    padding-top: 12px;
    margin-top: 12px;
}

.sequence-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 8px;
    flex-wrap: wrap;
    gap: 8px;
}

.sequence-header h4 {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--color-gray-700);

}

.sequence-actions {
    display: flex;
    gap: 4px;
    align-items: center;
    margin: 0;
}

.sequence-info {
    font-size: 0.7rem;
    color: var(--color-gray-500);
}

.sequence-container {
    overflow-x: auto;
    padding: 5px 0;
}

.sequence-row {
    display: flex;
    align-items: center;
    gap: 8px;
    white-space: nowrap;
    margin-bottom: 4px;
}

.sequence-label {
    font-weight: bold;
    font-size: 0.7rem;
    min-width: 50px;
}

.chain-a-label { color: #e74c3c; }
.chain-b-label { color: #3498db; }

.sequence-residues {
    display: flex;
    font-family: 'Courier New', monospace;
    font-size: 10px;
}

.sequence-residue {
    width: 12px;
    height: 16px;
    display: flex;
    align-items: center;
    justify-content: center;
    cursor: pointer;
    border-radius: 2px;
    transition: background-color 0.1s;
}

.sequence-residue:hover {
    background-color: #e0e0e0;
}

.sequence-residue.highlighted {
    background-color: #00d4aa;
    color: white;
}

.sequence-residue.selected {
    background-color: #3498db;
    color: white;
    font-weight: bold;
}

.sequence-ruler {
    display: flex;
    font-family: 'Courier New', monospace;
    font-size: 8px;
    color: #999;
    margin-left: 58px;
    margin-bottom: 2px;
}

.sequence-ruler-mark {
    width: 12px;
    text-align: center;
}

/* pLDDT Legend */
.plddt-legend {
    display: flex;
    gap: 8px;
    flex-wrap: wrap;
    margin-top: 8px;
    font-size: 0.65rem;
}

.plddt-legend-item {
    display: flex;
    align-items: center;
    gap: 3px;
}

.plddt-legend-color {
    width: 12px;
    height: 12px;
    border-radius: 2px;
}

/* Loading state */
.loading-indicator {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 10px;
    padding: 40px;
    color: var(--color-gray-500);
}

.loading-spinner {
    width: 24px;
    height: 24px;
    border: 3px solid var(--color-gray-200);
    border-top-color: var(--color-primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
}

@keyframes spin {
    to { transform: rotate(360deg); }
}


/* 404.html style block 1 */
.error-page {
    display: flex;
    align-items: center;
    justify-content: center;
    min-height: 60vh;
}

.error-content {
    text-align: center;
}

.error-content h1 {
    font-size: 6rem;
    font-weight: 700;
    color: var(--color-gray-300);
    margin-bottom: 0;
}

.error-content h2 {
    font-size: 1.5rem;
    color: var(--color-gray-700);
    margin-bottom: 12px;
}

.error-content p {
    color: var(--color-gray-500);
    margin-bottom: 24px;
}


/* 500.html style block 1 */
.error-page {
    display: flex;
    align-items: center;
    justify-content: center;
    min-height: 60vh;
}

.error-content {
    text-align: center;
}

.error-content h1 {
    font-size: 6rem;
    font-weight: 700;
    color: var(--color-danger);
    margin-bottom: 0;
}

.error-content h2 {
    font-size: 1.5rem;
    color: var(--color-gray-700);
    margin-bottom: 12px;
}

.error-content p {
    color: var(--color-gray-500);
    margin-bottom: 24px;
}